Upstream Process Development

Our goal during upstream process development is to develop high titer, scalable production processes that will express our customer’s target molecules expressed via microbial fermentation (e.g., E. coli, P. pastoris), cell culture systems including CHO, HEK, Vero, MDCK, EB66 and insect cells, and from transgenic sources.

Upstream Solutions for Long Term Success

Upstream Development

We have modern facilities with access to state- of- the art equipment. With over 40 fermentors (1-100L) and over 50 bioreactors (3-200L), as well as ambr systems (24x 250ml and 48x 15ml), FUJIFILM’s scientists develop and optimize batch and fed batch processes, for microbial, mammalian or baculovirus-based production.

We also have experience to work with Hollow Fiber and Stack Cell Culture Systems.

Furthermore, we can generate and qualify scale down-models and fully characterize process parameters in support of process validation. Extensive use is made of DOE approaches, with the support of in-house statisticians.

Upstream Development Activities include:

  • Stewart DemoProcess Transfer-in and Development
  • Process monitoring
  • Recovery of Solids or Soluble Material
  • Cell Disruption
  • Supply & Toxicology Study Supply Batches
  • Process Characterization